Thousands of X-miR microRNA repressors available.
By specifically targeting microRNA with Oligoengine's exclusive X-miR products, researchers can specifically repress individual miRNA. Oligoengine offers stable, inducible pSUPERIOR X-miR's or Synthetic X-miR for transient use.
Repressing microRNA
Mature microRNA's can be specifically repressed using Oligoengine's exclusive X-miR products. The X-miR is designed to bind to your target microRNA and inhibits function. X-miR's can be used as transient RNA or integrated into pSUPER RNAi vectors. For your convenience, Oligoengine offers both pSUPERIOR X-miR Clones or synthetic X-miR oligos.
Stable or Transient X-miR
The X-miR microRNA repressor can be constitutively expressed by inducible pSUPERIOR or transiently as synthetic RNA.
Inducible transfection-ready X-miR Clones: $499 each
Synthetic ligation-ready DNA X-miR: $299 /oligo pair
Synthetic RNA X-miR: $399 each
X-miR Serum Stability
Transient use of synthetic X-miR RNA is enhanced by the exonuclease resistance charactaristic of it's novel structure.
Custom designed X-miR's
Thousands are pre-designed for specificity against individual miRNA's, but with new miRNA's discovered weekly, Oligoengine is ready to design X-miR specific to your needs.
Getting started with X-miR microRNA repressors
X-miR oligos can be used transiently as RNA or expressed constitutively from pSUPER/pSUPERIOR vectors. Either way, an understanding of the simple design parameters is required. Oligoengine offers design assistance for any custom X-miR as well as a library of pre-designed versions.
Mature microRNA
As non-coding regulatory elements, microRNA can be specifically repressed by X-miR oligo constructs.
Basic X-miR Design
Oligoengine designs X-miR specifically to a targeted nucleotides of a mature microRNA.
X-miR Design Overview
Serum Stability
MircroRNA repression efficacy is enhanced by exonuclease resistance.
X-miR Results
Gene modulation results by microRNA repression will vary depending upon function of the microRNA itself. The X-miR construct is designed to hybridize to the targeted nucleotides on the mature microRNA to inhibit regulatory function.
Price List.
X-miR constructs are available as transfection-ready clones, ligation-ready DNA, synthetic RNA for transient use.
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pSUPER X-miR: | ||
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X-miR-0001 | pSUPER X-miR (DNA Set) | $299 |
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X-miR-0002 | pSUPER X-miR (Clone) | $499 |
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Synthetic X-miR: | ||
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X-miR-0003 | Synthetic X-miR (RNA, 40 nm) | $399 |
Custom X-miR
Oligoengine can design your microRNA targeting X-miR. Design requests can be done via email or Fax-back forms.
Stock X-miR
Oligoengine 3.0 contains a listing of thousands of stock X-miR designs as well as tools for real-time design of your custom X-miR.
X-miR Fax-Back Order Form
Use this fax form to place your X-miR order.
X-miR Clones:
Any microRNA + pSUPER or pSUPERIOR + 18 Days.
Pick any pSUPER or pSUPERIOR vector, a microRNA target, and we will send a sequenced X-miR clones for $499 each.
Cloning Service Deliverables:
• All clones are sequence confirmed.
• 18 Business Day turnaround.
• Price includes all materials.
• Delivered as miniprep, ~4 µg.
Cloning Fax Form.
Questions and Answers
Common Questions for X-miR.
Can I design my own X-miR?
> For best results, please request design and product quotes from Oligoengine via the fax forms or Oligoengine software.
Will X-miR work with other vectors?
> Yes, we can provide ligation-ready X-miR for your vector.
Is X-miR microRNA repression guaranteed?
> We are not yet able to guarantee its use against all microRNA. For the best results, send us your targets for designing.
Can I order my X-miR from another supplier?
> At the moment, X-miR microRNA repressors are exclusive to Oligoengine. Licenses to other suppliers will be considered in the future.
Can I order X-miR oligos and clones internationally?
> Yes, Oligoengine will ship them to most countries or provide them through a supplier.
X-miR Licensing.
X-miR licenses are part of the AsymmetricRNAi Platform.
Academic and Non-Profit Licensing Terms
Researchers at academic and non-profit institutions are granted a limited end-user license with the purchase of each X-miR.
Commercial and For-Profit Licensing Terms
Use of the AsymmetricRNAi Platform, including X-miR, by commercial pharmacuetical and biotech companies is subject to specific licensing terms.
Companies can purchase individual X-miR molecules and vectors before negotiating a streamlined product use agreement. Additionally, any products, including cell lines, transgenic animals and therapeutic compounds developed using X-miR will be considered as licensed products and subject to a sales royalty by Halo-Bio RNAi Therapeutics Inc..
For more information, please contact OligoEngine.